Johnston RL, Tufail A, Lightman S, Luthert PJ, Pavesio CE, Cooling RJ, Charteris D. Retinal and choroidal biopsies are helpful in unclear uveitis of suspected infectious or malignant origin. Ophthalmology 2004; 111:522-528.
Liaise with laboratory to ensure that:
There are two main approaches to choroidal biopsy:
Using a vitreous cutter has the following advantages: Direct (rather than inverted) visualization, control of intra-ocular pressure for hemostasis, usually able to obtain a larger specimen.
FNAB has the following advantages: Cost-saving, avoids cataract (although this is not an issue if the vitreous cutter is used with minimal vitrectomy), the bore of the needle is perpendicular to the retinal plane, unlike the cutter port which is parallel.
The trans approach is best for anterior tumors.
FNAB has the following advantages: Simpler, less complications such as hemorrhage.
Incisional has the following advantages: Able to obtain a larger specimen.
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